PHYSICAL PROPERTIES AND RATE OF DIFFUSION TRANSETHOSOME CURCUMIN USING A COMBINATION OF TWEEN 60 AND SPAN 60 AS SURFACTANT

Objective: Curcumin penetration can be increased by formulating it into the transethosome system. Surfactant is one of components that affect physical properties and vesicles. In this study, a combination two surfactants was used to see effect on curcumin penetration.
 Methods: This study tween 60 span with concentration ratio 0:5 (F1), 1:1 (F2), 2:1 (F3), 1:2 (F4). An evaluation included testing distribution particle size, zeta potential, entrapment efficiency in Evaluation continued determination diffusion rate vitro. 
 Results: The system formed has size 167.9±4.7 nm-396±3.7 nm potential value (-) 49.54±1.77 mV-(-) 59.05±0.95 mV, polydispersion index 0.0%-57.1% 83.76%-93.75%. F1 F3 followed Higuchi kinetics model, while F2 F4 zero-order Korsmeyer-Peppas kinetics.
 Conclusion: could form nano-sized curcumin. Diffusion results show using surfactant increase curcumin, where there significant difference between each formula (p<0.05).